Synthesis, Antiviral and Antimicrobial Activities of Quinazoline Urea Analogues

A new series of quinazoline urea were synthesized and evaluated for antiviral and antimicrobial activity. Compound 4k [1-(2-chlorophenyl)-3-(4-oxo-2-phenylquinazolin-3(4H)-yl) urea] inhibited the replication of influenza A H1N1, influenza A H3N2 and influenza B at EC50 of 0.025 μM. Compound 4e [1-(2-methyl-4-oxoquinazolin-3(4H)-yl)-3-(4nitrophenyl) urea] was found to potentially inhibits replication of Coxsackie virus B4, Vesiculat stomatitis virus and Respiratory syncytial virus at EC50 of 0.029 μM. The compounds were also tested for their in vitro antibacterial and antifungal activity against pathogenic microbes. Compound 4j [1-(4-oxo-2-phenylquinazolin-3(4H)-yl)-3-o-tolylurea] had displayed potent activity (1.56-3.12 μg/ml) against B. subtitlis, S. aureus and P. auroginosa. Compound 4v [1-(2-(4chlorophenyl)-4-oxoquinazolin-3(4H)-yl)-3-(2-nitrophenyl)urea] was potent against C. albicans (3.12 μg/ml). It can be concluded that the compound 4k could be used as a scaffold for the development of anti-influenza agents.